Differentiating atypical parkinsonian syndromes—a way forward?

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Differentiating atypical parkinsonian syndromes—a way forward?

Any neurologist—even a movement disorders neurologist, if he or she is honest, will tell you that it can be maddeningly difficult to differentiate between Parkinson’s disease (PD) and the atypical parkinsonian syndromes (APS) such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), especially during their initial clinical stages. Although...

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Redefinition of Atypical Parkinsonian Syndromes

The term “atypical parkinsonian syndrome” is traditionally used for several neurodegenerative diseases, including multiple system atrophy (MSA), dementia with Lewy bodies (DLB), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP). Their defining commonality consists in their akinetic-rigid extrapyramidal movement disorder. In contrast to idiopathic Parkinson’s disease (PD)...

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Neuropathology of Atypical Parkinsonian Disorders

Although the clinical syndrome of parkinsonism (rigidity, bradykinesia, and tremor) is most often owing to idiopathic Parkinson’s disease (PD), it may also be associated with a variety of other underlying pathologies (Table 1) (1–3). Each of these other pathological conditions tends to have a characteristic clinical phenotype, however atypical cases are increasingly recognized (4–8). Moreover, ...

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Rehabilitation of Patients With Atypical Parkinsonian Disorders

Atypical parkinsonism encompasses several disorders that may have disease-specific or individualspecific characteristics, however common features include akinesia, rigidity, gait difficulties, and cognitive decline with gradual worsening of the symptoms. These features result in a variety of deficits that affect the patient’s ability to function in their usual capacity at home, on the job, and ...

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Cognitive bedside assessment in atypical parkinsonian syndromes.

BACKGROUND Despite the growing recognition of the importance of cognitive symptoms for the diagnosis and management of atypical parkinsonian syndromes, the cognitive assessment of the patients in clinical practice often remains very limited. OBJECTIVES To examine the ability of a brief and simple cognitive screening test to detect cognitive deficits in atypical parkinsonian syndromes. METHO...

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ژورنال

عنوان ژورنال: Brain and Behavior

سال: 2015

ISSN: 2162-3279,2162-3279

DOI: 10.1002/brb3.341